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  MANET provides numerous functionalities, which enable searching for specific protein folds with defined ancestry values, displaying the distribution of enzymes that are "painted" in individual metabolic subnetworks, and exploring evolutionary patterns in subnetworks and mesonetworks.
1. Each enzyme in the diagram is hyper-linked to the KEGG database so that the user can retrieve additional information by clicking in the diagram.
2. We recommend using either Nescape Navigator or Internet Explore browsers.
3. "sf" labels on enzyme entries indicate that the ancestry information was predicted using Hidden Markov Models(HMMs).